S3 Freeze-Thaw System
The Celsius S3 is the only small-volume Controlled Freeze-Thaw System in disposable containers that is scalable to production volume. This system is a tool to execute freeze-thaw process development and stability studies using a minimal amount of product.
Scalability
The Celsius S3 System models both a 16.6 L pilot-scale system and a 100 L production system with a minimal amount of product. Using the same freeze and thaw path-length and identical materials of construction in all Celsius-Pak containers, the Celsius S3 System ensures unmatched scalability between all scale systems.
The Celsius S3 System can also mimic a slow freezing process. Obviously, the "slow freezing" profile will need to be looked at as an indication only of how the product will react, not as a scalable process. Freeze type, loading, set point temperature and placement within the freezer will impact the overall freezing rate.
With this "slow freezing" profile and our standard controlled freezing profile, the Celsius S3 System help choosing which freezing process is best for one product, either a controlled (Celsius CFT) or uncontrolled freeze (Celsius FFT).
Ease of Use
The CryoPilot Control Unit provides automated operation and data collection. The Celsius S3 System freezes and thaws from 1 to 10 product samples per run. Celsius-Paks are available in 30 mL and 100 mL with different filling line configurations.
Key Features
- Technology platform scale-down
- Stability studies
- Development studies
Celsius S3 : Scale-down and Stability Studies
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Celsius S3